Literature summary for 2.7.7.49 extracted from

Ono, K.; Nakane, H.; Herdewijn, P.; Balzarini, J.; De Clerq, E.
Inhibitory effects of various derivatives of azidothymidine triphosphate on reverse transcriptase and DNA polymerases (1988), Nucleic Acids Res., 20, 5-6.

No PubMed abstract available

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Inhibitors

Inhibitors	Comment	Organism	Structure
2',3'-Didehydro-2',3'-dideoxycytidine 5'-triphosphate	-	Rauscher murine leukemia virus
2',3'-didehydro-2',3'-dideoxythymidine 5'-triphosphate	strong but nonspecific inhibitor	Rauscher murine leukemia virus
3'-Azido-2',3'-dideoxythymidine 5'-diphosphate	-	Rauscher murine leukemia virus
3'-Azido-2',3'-dideoxythymidine 5'-triphosphate	most potent and selective inhibitor	Rauscher murine leukemia virus

Organism

Organism	UniProt	Comment	Textmining
Rauscher murine leukemia virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Rauscher murine leukemia virus	diphosphate + DNAn+1	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.042	-	3'-Azido-2',3'-dideoxythymidine 5'-triphosphate	-	Rauscher murine leukemia virus

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Release 2023.1 (January 2023)