Literature summary for 2.7.7.49 extracted from

Murakami, E.; Feng, J.Y.; Lee, H.; Hanes, J.; Johnson, K.A.; Anderson, K.S.
Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication (2003), J. Biol. Chem., 278, 36403-36409.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	Homo sapiens	DNA polymerase Pol gamma also catalyzes reverse transcription with a slightly higher efficiency than HIV-1 reverse transcriptase. RNA-primed DNA synthesis activity is required for initiation of mtDNA replication. Poly gamma holoenzyme is capable of performing this reaction at a physiologically releavant rate	diphosphate + DNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	DNA polymerase Pol gamma also catalyzes reverse transcription with a slightly higher efficiency than HIV-1 reverse transcriptase	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	DNA polymerase Pol gamma also catalyzes reverse transcription with a slightly higher efficiency than HIV-1 reverse transcriptase	Homo sapiens	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	DNA polymerase Pol gamma also catalyzes reverse transcription with a slightly higher efficiency than HIV-1 reverse transcriptase. RNA-primed DNA synthesis activity is required for initiation of mtDNA replication. Poly gamma holoenzyme is capable of performing this reaction at a physiologically releavant rate	Homo sapiens	diphosphate + DNAn+1	-	?

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Release 2023.1 (January 2023)