Literature summary for 2.7.7.48 extracted from

Yokokawa, F.; Nilar, S.; Noble, C.G.; Lim, S.P.; Rao, R.; Tania, S.; Wang, G.; Lee, G.; Hunziker, J.; Karuna, R.; Manjunatha, U.; Shi, P.Y.; Smith, P.W.
Discovery of potent non-nucleoside inhibitors of Dengue viral RNA-dependent RNA polymerase from a fragment hit using structure-based drug design (2016), J. Med. Chem., 59, 3935-3952.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	structure-based drug design of potent non-nucleoside inhibitors of Dengue viral RNA-dependent RNA polymerase, -ray-based fragment screening, overview. A biphenyl acetic acid fragment 3 binds in the palm subdomain of RdRp, 1000fold improvement in potency in vitro and acquired antidengue activity against all four serotypes with low micromolar EC50 in cell-based assays	Dengue virus

Organism

Organism	UniProt	Comment	Textmining
Dengue virus	-	-	-

Synonyms

Synonyms	Comment	Organism
RDRP	-	Dengue virus
RNA-dependent RNA polymerase	-	Dengue virus

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Release 2023.1 (January 2023)