Organism | UniProt | Comment | Textmining |
---|---|---|---|
influenza A virus | - |
standard activity strains A/WSN/33, H1N1, and A/NT/60/68, H3N2, and increased activity strains A/HongKong/156/97, H5N1, and A/Vietnam/1194/04, H5N1 | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
strains A/WSN/33, H1N1, and A/NT/60/68, H3N2, show standard RNA polymerase activity, while strains A/HongKong/156/97, H5N1, and A/Vietnam/1194/04, H5N1, show increased polymerase activity correlated with enhanced promoter binding. The N-terminal region of the PA subunit is the major determinant of this enhanced promoter activity | influenza A virus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the heterotrimeric complex of PB1, PB2 and PA subunits cooperate in the transcription and replication of the viral genome, the N-terminal region of the PA subunit of two recent H5N1 strains can influence promoter binding and RNA polymerase activity as well as virulence of the strains, overview | influenza A virus | ? | - |
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Subunits | Comment | Organism |
---|---|---|
heterotrimer | the RNA polymerase of influenza virus is a heterotrimeric complex of PB1, PB2 and PA subunits, which cooperate in the transcription and replication of the viral genome. The N-terminal region of the PA subunit of two recent H5N1 strains can influence promoter binding | influenza A virus |
Synonyms | Comment | Organism |
---|---|---|
RNA polymerase | - |
influenza A virus |
General Information | Comment | Organism |
---|---|---|
additional information | the RNA polymerase of influenza virus is a heterotrimeric complex of PB1, PB2 and PA subunits, which cooperate in the transcription and replication of the viral genome | influenza A virus |