Protein Variants | Comment | Organism |
---|---|---|
I482S | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
I482T | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
M423I | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
M423T | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
M423V | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
M426T | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
V494A | mutant confers resistance to AG-021541 and structurally related compounds but remains sensitive to interferon and HCV polymerase inhibitors known to interact with the active site or other allosteric sites of the protein | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[2-chloro-4-(2-[2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl)phenyl]-2-methylpropanenitrile | - |
Hepacivirus C | |
2-[4-(2-[2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl)-2-fluorophenyl]-2-methylpropanenitrile | - |
Hepacivirus C | |
6-[2-(5-chloro-2,4-dimethoxyphenyl)ethyl]-6-cyclopentyl-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one | AG-021541 | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Hepacivirus C | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS5B protein | - |
Hepacivirus C |
RNA-dependent RNA polymerase | - |
Hepacivirus C |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000004 | - |
wild type enzyme | Hepacivirus C | 2-[4-(2-[2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl)-2-fluorophenyl]-2-methylpropanenitrile | |
0.00002 | - |
wild type enzyme | Hepacivirus C | 6-[2-(5-chloro-2,4-dimethoxyphenyl)ethyl]-6-cyclopentyl-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one | |
0.000036 | - |
wild type enzyme | Hepacivirus C | 2-[2-chloro-4-(2-[2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl)phenyl]-2-methylpropanenitrile |