Literature summary for 2.7.7.48 extracted from

Ellingham, M.; Bunka, D.H.; Rowlands, D.J.; Stonehouse, N.J.
Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus (2006), RNA, 12, 1970-1979.

Search for more literature for 2.7.7.48

Inhibitors

Inhibitors	Comment	Organism	Structure
aptamer F38	identification and characterization of aptamers to the 3Dpol enzyme (serotype C). Three of these RNA molecules display inhibitory activity in an in vitro UTP incorporation assay	Foot-and-mouth disease virus
aptamer F47	identification and characterization of aptamers to the 3Dpol enzyme (serotype C). Three of these RNA molecules display inhibitory activity in an in vitro UTP incorporation assay	Foot-and-mouth disease virus
aptamer F52	identification and characterization of aptamers to the 3Dpol enzyme (serotype C). Three of these RNA molecules display inhibitory activity in an in vitro UTP incorporation assay	Foot-and-mouth disease virus

Organism

Organism	UniProt	Comment	Textmining
Foot-and-mouth disease virus	-	-	-

Synonyms

Synonyms	Comment	Organism
3Dpol	-	Foot-and-mouth disease virus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000018	-	aptamer F47	-	Foot-and-mouth disease virus
0.000021	-	aptamer F38	-	Foot-and-mouth disease virus
0.000075	-	aptamer F52	-	Foot-and-mouth disease virus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000106	-	-	Foot-and-mouth disease virus	aptamer F47
0.0000158	-	-	Foot-and-mouth disease virus	aptamer F38
0.0000164	-	-	Foot-and-mouth disease virus	aptamer F52

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Release 2023.1 (January 2023)