Literature summary for 2.7.7.48 extracted from

Cramer, J.; Jaeger, J.; Restle, T.
Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4) (2006), Biochemistry, 45, 3610-3619.

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Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	genotype-1b. HC-J4 NS5BDELTA21, a C-terminally truncated polymerase based on the consensus sequence of pCV-J4L6S	-

Subunits

Subunits	Comment	Organism
monomer	monomers are observed at NaCl concentrations above 300 mM. Binding of short RNA substrates leads to a further increase in oligomerization, whereas GTP does not show any effect on protein/protein interactions. Nucleotide incorporation studies indicate the oligomerization state does not correlate with enzymatic activities	Hepacivirus C
oligomer	highly oligomeric at low salt concentrations	Hepacivirus C

Synonyms

Synonyms	Comment	Organism
HC-J4 NS5BDELTA21	a C-terminally truncated polymerase based on the consensus sequence of pCV-J4L6S	Hepacivirus C
RNA-dependent RNA polymerase NS5B	-	Hepacivirus C

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Release 2023.1 (January 2023)