Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Murine respirovirus | |
Na+ | - |
Murine respirovirus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Murine respirovirus | the enzyme catalyzes cap methylation of virus-specific mRNA as well as RNA synthesis | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Murine respirovirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | the enzyme catalyzes cap methylation of virus-specific mRNA as well as RNA synthesis | Murine respirovirus | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | viral ribonucleoprotein complexes and purified recombinant L protein but not P protein exhibit mRNA (guanine-7-)methyl-transferase activity. mRNA synthesis in a reconstituted transcription system using purified N protein-genomic RNA complex as a template requires both the L and P proteins. Enzymatic properties of Senda virus mRNA (guanine-7-)methyl-transferase are different to that of cellular mRNA (guanine-7-)methyl-transferase. Unlike cellular enzyme, the SeV enzyme preferentially methylates capped RNA containing the viral mRNA 5'-end sequences (GpppApGpG-). The C-terminal part (amino acid residues 1,7562,228) of the L protein catalyzes cap methylation, whereas the N-terminal half (residues 11,120) containing putative RNA polymerase subdomains does not | Murine respirovirus | diphosphate + RNAn+1 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | RNA-dependent RNA polymerase complex, which consists of L protein (250000 Da) and P proteins (80000 Da) | Murine respirovirus |
Synonyms | Comment | Organism |
---|---|---|
RNA-dependent RNA polymerase | - |
Murine respirovirus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Murine respirovirus |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | 45 | 30°C: optimum, 45°C: 50-80% of maximal activity | Murine respirovirus |