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Literature summary for 2.7.7.47 extracted from

  • Clark, N.C.; Olsvik, O.; Swenson, J.M.; Spiegel, C.A.; Tenover, F.C.
    Detection of a streptomycin/spectinomycin adenylyltransferase gene (aadA) in Enterococcus faecalis (1999), Antimicrob. Agents Chemother., 43, 157-160.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.47

Application

Application Comment Organism
medicine streptomycin continues to be an important drug for synergistic therapy of serious enterococcal infections Enterococcus faecalis

Cloned(Commentary)

Cloned (Comment) Organism
aadA resistence gene transferred vi filter mating from Enterococcus faecalis W4770 to Enterococcus faecalis JH2-2, PCR amplified aadA gene cloned into vector pCRII and transformed into Escherichia coli DH5-alpha Enterococcus faecalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + streptomycin Enterococcus faecalis
-
 diphosphate + 3''-adenylylstreptomycin
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 ?

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis Q71UU1 W4770, aadA nucleotide sequence
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + spectinomycin
-
 Enterococcus faecalis diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + streptomycin
-
 Enterococcus faecalis diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + tetracyclin
-
 Enterococcus faecalis diphosphate + 3''adenylyltetracyclin
-
 ?
additional information no resistance to ampicillin, chloramphenicol, ciprofloxacin, gentamicin, imipenem, penicillin, quinupristin/dalfopristin, rifampin, teicoplanin, and vancomycin mediated Enterococcus faecalis ?
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 ?