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Literature summary for 2.7.7.38 extracted from
- The cytidyltransferases family: Properties, kinetics, genomic and phylogeny (2003), Recent Res. Devel. Biochem., 4, 224-254.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | - |
Escherichia coli |
| medicine | KDO is not present in animals but is vital for gram-negative bacteria, suggests the possibility of using selective inhibition of its synthesis as antibacterial tool | Haemophilus influenzae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Escherichia coli |
| KDO-CT crystallized in presence of CMP-NeuAc, crystallizes as a dimer composed of 27kDa monomers | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate | - |
Escherichia coli |  |
| 2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.024 | 0.8 | CTP | - |
Escherichia coli | |
| 0.024 | 0.8 | CTP | - |
Zea mays | |
| 0.29 | - |
3-deoxy-D-manno-octulosonate | - |
Escherichia coli | |
| 0.9 | - |
3-deoxy-D-manno-octulosonate | - |
Escherichia coli | |
| 2.5 | - |
CTP | isoenzyme K-KDO-CT | Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | can partially substitute Mg2+ | Escherichia coli | |
| Ca2+ | can partially substitute Mg2+ | Escherichia coli | |
| Cd2+ | can partially substitute Mg2+ | Escherichia coli | |
| Co2+ | can partially substitute Mg2+ | Escherichia coli | |
| Mn2+ | can partially substitute Mg2+ | Escherichia coli | |
| Zn2+ | can partially substitute Mg2+ | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + 3-deoxy-D-manno-octulosonate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Chlamydia trachomatis | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Haemophilus influenzae | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Escherichia coli | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Zea mays | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Pseudomonas aeruginosa | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Neisseria meningitidis | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Helicobacter pylori | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Rickettsia prowazekii | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Aquifex aeolicus | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Chlamydia muridarum | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Chlamydia pneumoniae | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Pasteurella multocida | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Arabidopsis thaliana | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Caulobacter vibrioides | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Mesorhizobium loti | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Rickettsia conorii | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Sinorhizobium meliloti | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Vibrio cholerae | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Xylella fastidiosa | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | Neisseria meningitidis MC58 | - |
diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aquifex aeolicus | - |
- |
- |
| Arabidopsis thaliana | Q9C920 | - |
- |
| Caulobacter vibrioides | Q9A4A3 | - |
- |
| Chlamydia muridarum | - |
- |
- |
| Chlamydia pneumoniae | - |
- |
- |
| Chlamydia trachomatis | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Escherichia coli | P42216 | PDB: 1H7F, 3-dimensional structure of KDO-CT, in presence of CMP | - |
| Escherichia coli | P42216 | PDB: 1H7T, 3-dimensional structure of KDO-CT, in presence of CMP-NeuAc | - |
| Escherichia coli | P42216 | PDB: 1H7H, 3-dimensional structure of KDO-CT, in presence of CTP | - |
| Escherichia coli | P42216 | PDB: 1H7G, 3-dimensional structure of KDO-CT, in presence of CDP | - |
| Escherichia coli | P42216 | PDB:1H7E, 3-dimensional structure of KDO-CT, unligated form | - |
| Haemophilus influenzae | - |
- |
- |
| Helicobacter pylori | - |
- |
- |
| Mesorhizobium loti | Q98BN3 | - |
- |
| Neisseria meningitidis | - |
- |
- |
| Neisseria meningitidis | Q9K0D6 | strain B | - |
| Neisseria meningitidis MC58 | Q9K0D6 | strain B | - |
| Pasteurella multocida | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Rickettsia conorii | Q92I96 | - |
- |
| Rickettsia prowazekii | - |
- |
- |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| Sinorhizobium meliloti | Q92SX6 | - |
- |
| Vibrio cholerae | Q9KQX2 | - |
- |
| Xylella fastidiosa | Q9PB46 | - |
- |
| Zea mays | - |
maize | - |
| Zea mays | Q9M4D3 | maize, KDO-CT fragment | - |
| Zea mays | Q9M4G3 | maize, KDO-CT precursor | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + 3-deoxy-D-manno-octulosonate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Chlamydia trachomatis | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Haemophilus influenzae | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Escherichia coli | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Zea mays | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Pseudomonas aeruginosa | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Neisseria meningitidis | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Helicobacter pylori | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Rickettsia prowazekii | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Aquifex aeolicus | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Chlamydia muridarum | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Chlamydia pneumoniae | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Pasteurella multocida | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Arabidopsis thaliana | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Caulobacter vibrioides | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Mesorhizobium loti | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Rickettsia conorii | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Sinorhizobium meliloti | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Vibrio cholerae | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Xylella fastidiosa | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| CTP + 3-deoxy-D-manno-octulosonate | - |
Neisseria meningitidis MC58 | diphosphate + CMP-3-deoxy-D-manno-octulosonate | - |
r | |
| dCTP + 3-deoxy-D-manno-octulosonate | - |
Chlamydia trachomatis | diphosphate + dCMP-3-deoxy-D-manno-octulosonate | - |
r | |
| dCTP + 3-deoxy-D-manno-octulosonate | - |
Escherichia coli | diphosphate + dCMP-3-deoxy-D-manno-octulosonate | - |
r | |
| additional information | - |
Chlamydia trachomatis | ? | - |
? | |
| additional information | 3-deoxy-D-manno-octulosonate-8-phosphate is no substrate, neither NeuAc nor 3-deoxy-arabinoheptulosonate or 3-deoxy-erythro-hexulosonate are substrates | Escherichia coli | ? | - |
? | |
| UTP + 3-deoxy-D-manno-octulosonate | 12% of the activity with CTP as substrate | Chlamydia trachomatis | diphosphate + UMP-3-deoxy-D-manno-octulosonate | - |
r | |
| UTP + 3-deoxy-D-manno-octulosonate | nearly the same activity with CTP as pH 9.5, more active with CTP at pH 7.0 | Zea mays | diphosphate + UMP-3-deoxy-D-manno-octulosonate | - |
r | |
| UTP + 3-deoxy-D-manno-octulosonate | reaction at pH 9.5, approximately 50% the rate with CTP | Escherichia coli | diphosphate + UMP-3-deoxy-D-manno-octulosonate | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| K-KDO-CT | - |
Escherichia coli |
| KDO-CT | - |
Escherichia coli |
| L-KDO-CT | - |
Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.3 | 9.6 | - |
Escherichia coli |
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