Literature summary for 2.7.7.31 extracted from

Repasky, J.A.; Corbett, E.; Boboila, C.; Schatz, D.G.
Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination (2004), J. Immunol., 172, 5478-5488.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
del1-232	mutant shows no appreciable activity	Mus musculus
del1-280	mutant shows no appreciable activity	Mus musculus
del421-501	mutant shows no appreciable activity	Mus musculus
del453-501	mutant shows no appreciable activity	Mus musculus
G257A/V258A/G259A	mutant shows no appreciable activity	Mus musculus
additional information	mutational analysis demonstrates that the N-terminal portion of Tft, including the BRCA-1 C-terminal domains, is nor required for TdT activity, although the BRCT domain clearly contributes quantitatively to N-nucleotide addition activity. The second helix-hairpin-helix domain of TdT, but not the first, is required for activity. Deletional analysis suggests that the entire C-terminal region of TdT is necessary for N-nucleotide addition in vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
terminal deoxynucleotidyltransferase	-	Mus musculus

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Release 2023.1 (January 2023)