Literature summary for 2.7.7.31 extracted from

Uchiyama, Y.; Tagami, J.; Kamisuki, S.; Kasai, N.; Oshige, M.; Chiku, H.; Ibe, S.; Koiwai, O.; Sugawara, F.; Sakaguchi, K.
Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin (2005), Biochim. Biophys. Acta, 1725, 298-304.

Search for more literature for 2.7.7.31

Inhibitors

Inhibitors	Comment	Organism	Structure
Baicalin	competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0186 mM	Homo sapiens
genistein	competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0287 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant	-

Synonyms

Synonyms	Comment	Organism
TdT	-	Homo sapiens
terminal deoxyribonucleotidyltransferase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00981	-	Baicalin	versus dNTP substrate	Homo sapiens
0.0152	-	Baicalin	versus DNA primer	Homo sapiens
0.0231	-	genistein	versus DNA primer	Homo sapiens
0.0338	-	genistein	versus dNTP substrate	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0186	-	competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0186 mM	Homo sapiens	Baicalin
0.0287	-	competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0287 mM	Homo sapiens	genistein

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Release 2023.1 (January 2023)