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Literature summary for 2.7.7.31 extracted from
- Selective inhibition of terminal deoxynucleotidyl transferase from leukemic cells by streptolydigin (1976), Biochem. Biophys. Res. Commun., 72, 1343-1349.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Streptolydigin | does not significantly inhibit DNA polymerase alpha, beta, and gamma, or RNA polymerase, non-competitive to (dA)12-18 and dGTP | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukemia cell | molt-4 cells and leukocytes of patient with acute lymphoblastic leukemia | Homo sapiens | - |
| leukocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | primer required | Homo sapiens | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | reaction is not template directed | Homo sapiens | diphosphate + DNAn+1 | - |
? | |
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