Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.3 extracted from

  • Zhao, L.; Allanson, N.M.; Thomson, S.P.; Maclean, J.K.F.; Barker, J.J.; Primrose, W.U.; Tyler, P.D.; Lewendon, A.
    Inhibitors of phosphopantetheine adenylyltransferase (2003), Eur. J. Med. Chem., 38, 345-349.
    View publication on PubMed
Search for more literature for 2.7.7.3

Crystallization (Commentary)

Crystallization (Comment) Organism
co-crystallization with inhibitor PTX040334 in 5% DMSO, 22-32% polyethylene glycol 8000, 200 mM ammonium sulfate in 100 mM cacodylate buffer, pH 6-6.5 at 21°C Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
PTX040334 IC50: 0.03 mM Escherichia coli
PTX040334 no inhibition Sus scrofa
PTX042695 IC50: 0.000006 mM Escherichia coli
PTX042695 no inhibition Sus scrofa

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pantetheine 4'-phosphate
-
 Escherichia coli diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate
-
 Sus scrofa diphosphate + 3'-dephospho-CoA
-
 r

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000006
-
 IC50: 0.000006 mM Escherichia coli PTX042695
0.03
-
 IC50: 0.03 mM Escherichia coli PTX040334