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Literature summary for 2.7.7.23 extracted from

  • Min, J.; Lin, D.; Zhang, Q.; Zhang, J.; Yu, Z.
    Structure-based virtual screening of novel inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU (2012), Eur. J. Med. Chem., 53, 150-158.
    View publication on PubMed
Search for more literature for 2.7.7.23

Crystallization (Commentary)

Crystallization (Comment) Organism
homology modeling of structure based on Haemophilus influenzae enzyme, PDB entry 2V0K Xanthomonas oryzae pv. oryzae

Inhibitors

Inhibitors Comment Organism Structure
luteolin minimal inhibitory concentration for growth of Xanthomonas oryzae pv. oryzae, 186 microg/ml Xanthomonas oryzae pv. oryzae
N'-[(4-chloro-3,5-dimethylphenoxy)acetyl]-2,4-dihydroxybenzohydrazide minimal inhibitory concentration for growth of Xanthomonas oryzae pv. oryzae, 420 microg/ml Xanthomonas oryzae pv. oryzae
N'1,N'6-bis[2-(naphthalen-2-yloxy)acetyl]hexanedihydrazide minimal inhibitory concentration for growth of Xanthomonas oryzae pv. oryzae, 302 microg/ml Xanthomonas oryzae pv. oryzae

Organism

Organism UniProt Comment Textmining
Xanthomonas oryzae pv. oryzae Q2P7P9 bifunctional UDP-N-acetylglucosamine diphosphorylase, EC 2.7.7.23, and glucosamine-1-phosphate N-acetyltransferase, EC 2.3.1.157
-
Xanthomonas oryzae pv. oryzae MAFF 311018 Q2P7P9 bifunctional UDP-N-acetylglucosamine diphosphorylase, EC 2.7.7.23, and glucosamine-1-phosphate N-acetyltransferase, EC 2.3.1.157
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-D-glucosamine 1-phosphate + UTP
-
 Xanthomonas oryzae pv. oryzae UDP-N-acetyl-alpha-D-glucosamine + diphosphate
-
 ?
N-acetyl-alpha-D-glucosamine 1-phosphate + UTP
-
 Xanthomonas oryzae pv. oryzae MAFF 311018 UDP-N-acetyl-alpha-D-glucosamine + diphosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00044
-
 luteolin substrate N-acetyl-alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C Xanthomonas oryzae pv. oryzae
0.00099
-
 luteolin substrate UTP, pH 7.5, 37°C Xanthomonas oryzae pv. oryzae
0.0081
-
 N'1,N'6-bis[2-(naphthalen-2-yloxy)acetyl]hexanedihydrazide substrate N-acetyl-alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C Xanthomonas oryzae pv. oryzae
0.0081
-
 N'1,N'6-bis[2-(naphthalen-2-yloxy)acetyl]hexanedihydrazide substrate UTP, pH 7.5, 37°C Xanthomonas oryzae pv. oryzae
0.0089
-
 N'-[(4-chloro-3,5-dimethylphenoxy)acetyl]-2,4-dihydroxybenzohydrazide substrate UTP, pH 7.5, 37°C Xanthomonas oryzae pv. oryzae
0.0194
-
 N'-[(4-chloro-3,5-dimethylphenoxy)acetyl]-2,4-dihydroxybenzohydrazide substrate N-acetyl-alpha-D-glucosamine 1-phosphate, pH 7.5, 37°C Xanthomonas oryzae pv. oryzae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00081
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae luteolin
0.014
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N'1,N'6-bis[2-(naphthalen-2-yloxy)acetyl]hexanedihydrazide
0.023
-
 pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N'-[(4-chloro-3,5-dimethylphenoxy)acetyl]-2,4-dihydroxybenzohydrazide