KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.23 | - |
UDP-N-acetyl-D-glucosamine | pH 8.5, 37°C, 5 mM diphosphate | Sus scrofa | |
0.29 | - |
N-acetyl-D-glucosamine 1-phosphate | pH 7.5, 37°C, 5 mM UTP | Sus scrofa | |
0.42 | - |
UTP | pH 7.5, 37°C, 10 mM N-acetyl-D-glucose 1-phosphate | Sus scrofa | |
1.1 | - |
N-acetyl-alpha-D-galactosamine 1-phosphate | pH 7.5, 37°C, 5 mM UTP | Sus scrofa | |
2.2 | - |
UDP-N-acetyl-D-galactosamine | pH 8.5, 37°C, 5 mM diphosphate | Sus scrofa | |
5.8 | - |
D-glucose 1-phosphate | pH 7.5, 37°C, 5 mM UTP | Sus scrofa | |
6.3 | - |
UDP-D-glucose | pH 8.5, 37°C, 5 mM diphosphate | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Sus scrofa | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | can partially replace Mn2+ | Sus scrofa | |
Mg2+ | can partially replace Mn2+ | Sus scrofa | |
Mn2+ | required for maximum activity, 0.5-1 mM | Sus scrofa | |
Ni2+ | can partially replace Mn2+ | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
64000 | - |
SDS-PAGE, degradation products at 57000 and 49000 Da | Sus scrofa |
125000 | - |
gel filtration | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
diphosphate + UDP-N-acetyl-D-glucosamine | Sus scrofa | amino sugar metabolism | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
diphosphate + UDP-N-acetyl-D-glucosamine | Sus scrofa | involved in formation of N-linked oligosaccharides | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Sus scrofa | - |
brain | - |
Sus scrofa | - |
heart | - |
Sus scrofa | - |
kidney | - |
Sus scrofa | - |
liver | - |
Sus scrofa | - |
lung | - |
Sus scrofa | - |
pancreas | very high activity | Sus scrofa | - |
spleen | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
14.9 | - |
purified enzyme | Sus scrofa |
Storage Stability | Organism |
---|---|
-20°C, 20 mM Tris-HCl, pH 7.5, 1 mM EDTA, 1 mM 2-mercaptoethanol, 4 months, 10% loss of activity | Sus scrofa |
0°C, 20 mM Tris-HCl, pH 7.5, 1 mM EDTA, 1 mM 2-mercaptoethanol, 0.05% NaN3, 5 months, 50% loss of activity | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diphosphate + UDP-glucose | - |
Sus scrofa | UTP + D-glucose 1-phosphate | - |
r | |
diphosphate + UDP-N-acetyl-D-galactosamine | - |
Sus scrofa | UTP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
r | |
diphosphate + UDP-N-acetyl-D-glucosamine | - |
Sus scrofa | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
diphosphate + UDP-N-acetyl-D-glucosamine | amino sugar metabolism | Sus scrofa | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
diphosphate + UDP-N-acetyl-D-glucosamine | involved in formation of N-linked oligosaccharides | Sus scrofa | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
UTP + N-acetyl-alpha-D-galactosamine 1-phosphate | - |
Sus scrofa | diphosphate + UDP-N-acetyl-D-galactosamine | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 64000, SDS-PAGE, gel filtration | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | 9 | UTP formation | Sus scrofa |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7.5 | most stable | Sus scrofa |