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Literature summary for 2.7.7.2 extracted from
- FAD synthesis and degradation in the nucleus create a local flavin cofactor pool (2013), J. Biol. Chem., 288, 29069-29080.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| additional information | subcellular localization analysis of the enzyme, overview | Rattus norvegicus | - |
- |
| nucleus | existence of FAD synthesizing and hydrolyzing activities involved in maintaining FAD homeostasis in isolated rat liver nuclei, overview | Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + FMN | Rattus norvegicus | - |
diphosphate + FAD | - |
? | |
| ATP + FMN | Rattus norvegicus Wistar | - |
diphosphate + FAD | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | D4A4P4 | - |
- |
| Rattus norvegicus Wistar | D4A4P4 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially by subcellular fractionation and nucleus preparation | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Rattus norvegicus | - |
| INS-1E cell | - |
Rattus norvegicus | - |
| insulinoma cell | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| myocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + FMN | - |
Rattus norvegicus | diphosphate + FAD | - |
? | |
| ATP + FMN | - |
Rattus norvegicus Wistar | diphosphate + FAD | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAD synthase | - |
Rattus norvegicus |
| FADS | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the last step in the metabolic pathway producing FAD, redox cofactor ensuring the activity of many flavoenzymes mainly located in mitochondria but also relevant for nuclear redox activities | Rattus norvegicus |
| physiological function | the enzyme catalyzes the last step in the metabolic pathway producing FAD, redox cofactor ensuring the activity of many flavoenzymes mainly located in mitochondria but also relevant for nuclear redox activities | Rattus norvegicus |
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Release 2023.1 (January 2023)
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