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Literature summary for 2.7.7.19 extracted from

  • Bresson, S.M.; Conrad, N.K.
    The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay (2013), PLoS Genet., 9, e1003893.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Organism

Organism UniProt Comment Textmining
Homo sapiens P51003
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Homo sapiens Q9BWT3
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Synonyms

Synonyms Comment Organism
PAPalpha
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 Homo sapiens
PAPgamma
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 Homo sapiens
PAPOLA
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 Homo sapiens
PAPOLG
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 Homo sapiens

General Information

General Information Comment Organism
physiological function inactivation of PAP-dependent hyperadenylation in cells leads to the upregulation of various ncRNAs, including snoRNA host genes, primary miRNA transcripts, and promoter upstream antisense RNAs. mRNAs with retained introns are susceptible to PABPN1 and PAPalpha/gamma-mediated decay. Transcripts are targeted for degradation due to inefficient export, a consequence of reduced intron number or incomplete splicing. A genetically-encoded poly(A) tail is sufficient to drive decay. Treatment with transcription inhibitors uncouples polyadenylation from decay, leading to runaway hyperadenylation of nuclear decay targets Homo sapiens