Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0ABF1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PcnB | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | mature tRNAs, which are normally not substrates for PAP I in wild-type cells, are rapidly polyadenylated as PAP I levels increase upon overexpression, leading to dramatic reductions in the fraction of aminoacylated tRNAs, cessation of protein synthesis and cell death. The toxicity associated with PAP I is exacerbated by the absence of either RNase T and/or RNase PH. Regulation of PAP I is critical not for preventing the decay of mRNAs, but rather for maintaining normal levels of functional tRNAs and protein synthesis | Escherichia coli |