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Literature summary for 2.7.7.19 extracted from

  • Yang, Q.; Nausch, L.W.; Martin, G.; Keller, W.; Doublie, S.
    Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases (2014), J. Mol. Biol., 426, 43-50.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
isoform PAPgamma bound to cordycepin triphosphate (3?dATP) and Ca2+, to 2.8 A resolution. One 3'-dATP and one Ca2+ are present in the active site of each PAP molecule. Strictly conserved catalytic residues Asp112 and Asp114 interact with Ca2+, which also ligates three non-bridging oxygens of the alpha, beta and gamma phosphates of 3'-dATP. PAPgamma closely resembles its PAPalpha ortholog Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BWT3
-
-

Synonyms

Synonyms Comment Organism
PAPOLG
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Homo sapiens
poly(A) polymerase gamma
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Homo sapiens