Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PAP phosphorylation of serine 537 by extracellular signal-regulated kinase increases its nonspecific polyadenylation activity | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in HeLa cells and in Escherichia coli | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S537A | the mutant catalytic domain is not phosphorylated by ERK | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PD98059 | induces partial inhibition of PAP phosphorylation at S537 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione affinity Sepharose column chromatography | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA | - |
Mus musculus | diphosphate + RNA(A)n | - |
? | |
additional information | PAP is a substrate for extracellular signal-regulated kinase | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAP | - |
Mus musculus |
poly(A) polymerase | - |
Mus musculus |