Application | Comment | Organism |
---|---|---|
drug development | polyadenylation inhibition represents one mode of action for 8-chloroadenosine and 8-aminoadenosine in hematological malignancies, among several possible mechanisms. RNA-directed drugs may offer a valuable strategy in targeting indolent cancers, such as multiple myeloma | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3'-dATP | - |
Saccharomyces cerevisiae | |
8-amino-ATP | C-8 substitution influences sugar pucker conformation, which may affect yPAP efficiently | Saccharomyces cerevisiae | |
8-aza-ATP | slight inhibition | Saccharomyces cerevisiae | |
8-azido-ATP | slight inhibition | Saccharomyces cerevisiae | |
8-bromo-ATP | halogen modification at C-8 may negatively affect the ability of the enzyme to activate the ATP substrate or to transfer the AMP group from the enzyme to the RNA substrate | Saccharomyces cerevisiae | |
8-chloro-ATP | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNAn | - |
Saccharomyces cerevisiae | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
poly(A) polymerase | - |
Saccharomyces cerevisiae |
yPAP | - |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
8-amino-ATP | incubation at 37 °C for 20 min | Saccharomyces cerevisiae | |
0.0063 | - |
3'-dATP | incubation at 37 °C for 20 min | Saccharomyces cerevisiae |