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Literature summary for 2.7.7.19 extracted from

  • Christofori, G.; Keller, W.
    Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro (1989), Mol. Cell. Biol., 9, 193-203.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ in presence of Mg2+ and a specificity factor required for correct cleavage at the poly(A) site of pre-mRNA Homo sapiens
Mn2+ nonspecific adenylation of RNA in presence of Mn2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000 60000 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA Homo sapiens the enzymatic machinery that catalyzes formation of 3'-ends of polyadenylated mRNAs consists of two distinct factors: a poly(A) polymerase and a cleavage/specificity factor required for the correct cleavage at the poly(A) site of pre-mRNA ?
-
 ?
ATP + RNA Homo sapiens involved in the 3'-end processing of mRNA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 HeLa cells
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA primer required Homo sapiens diphosphate + RNA(A)n
-
 ?
ATP + RNA enzyme also has cleavage activity Homo sapiens diphosphate + RNA(A)n
-
 ?
ATP + RNA the enzymatic machinery that catalyzes formation of 3'-ends of polyadenylated mRNAs consists of two distinct factors: a poly(A) polymerase and a cleavage/specificity factor required for the correct cleavage at the poly(A) site of pre-mRNA Homo sapiens ?
-
 ?
ATP + RNA involved in the 3'-end processing of mRNA Homo sapiens ?
-
 ?