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Literature summary for 2.7.7.19 extracted from

  • Abraham, A.K.; Jacob, S.T.
    Hydrolysis of poly (A) to adenine nucleotides by purified poly (A) polymerase (1978), Proc. Natl. Acad. Sci. USA, 75, 2085-2087.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Inhibitors

Inhibitors Comment Organism Structure
ADP inhibits hydrolytic reaction Rattus norvegicus
AMP inhibits hydrolytic reaction Rattus norvegicus
ATP inhibits hydrolytic reaction Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ more active in presence of Mn2+ than Mg2+ Rattus norvegicus
Mn2+ more active in presence of Mn2+ than Mg2+ Rattus norvegicus
Mn2+ optimal concentration: 0.50-0.75 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA Rattus norvegicus synthetic and hydrolytic activities are functions of the same molecule, the level of adenine nucleotides regulates synthesis and degradation of poly(A), the hydrolytic reaction is responsible for poly(A) shortening or turnover, poly(A) itself is a storage form of adenine nucleotides ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA primer required Rattus norvegicus diphosphate + RNA(A)n AMP is the predominant product of the hydrolysis, ADP and ATP are also formed r
ATP + RNA enzyme also catalyzes hydrolysis of poly(A) Rattus norvegicus diphosphate + RNA(A)n AMP is the predominant product of the hydrolysis, ADP and ATP are also formed r
ATP + RNA does not degrade poly(A) associated with poly(A)*poly(U) helical structure Rattus norvegicus diphosphate + RNA(A)n AMP is the predominant product of the hydrolysis, ADP and ATP are also formed r
ATP + RNA synthetic and hydrolytic activities are functions of the same molecule, the level of adenine nucleotides regulates synthesis and degradation of poly(A), the hydrolytic reaction is responsible for poly(A) shortening or turnover, poly(A) itself is a storage form of adenine nucleotides Rattus norvegicus ?
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 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4 8 in presence of Mn2+ Rattus norvegicus