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Literature summary for 2.7.7.18 extracted from

  • Sorci, L.; Blaby,I.K.; Rodionova, I.A.; De Ingeniis, J.; Tkachenko, S.; de Crécy-Lagard, V.; Osterman, A.L.
    uinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci (2013), J. Bacteriol., 195, 726-732.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
K891-0166
-
Streptococcus pyogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24350
-
calculated from amino acid sequence Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-nicotinate D-ribonucleotide Streptococcus pyogenes
-
diphosphate + deamido-NAD+
-
?
ATP + beta-nicotinate D-ribonucleotide Streptococcus pyogenes ATCC BAA-946
-
diphosphate + deamido-NAD+
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes Q5XDT7 serotype M6
-
Streptococcus pyogenes ATCC BAA-946 Q5XDT7 serotype M6
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-nicotinate D-ribonucleotide
-
Streptococcus pyogenes diphosphate + deamido-NAD+
-
?
ATP + beta-nicotinate D-ribonucleotide
-
Streptococcus pyogenes ATCC BAA-946 diphosphate + deamido-NAD+
-
?

Synonyms

Synonyms Comment Organism
M6_Spy0291 locus name Streptococcus pyogenes
sp.NadD
-
Streptococcus pyogenes

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0079
-
K891-0166 pH 7.5, 37°C Streptococcus pyogenes

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
pH 7.5, 37°C Streptococcus pyogenes K891-0166