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Literature summary for 2.7.7.15 extracted from

  • Goulbourne, C.N.; Malhas, A.N.; Vaux, D.J.
    The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-alpha (2011), J. Cell Sci., 124, 4253-4266.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
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nucleoplasmic reticulum
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 Homo sapiens 44195
-
nucleus CCT-alpha forms intranuclear foci that colocalise with invaginations in prelamin-A-accumulating cells, overview Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
CCT-alpha
-
 Homo sapiens
choline-phosphate cytidylyltransferase A
-
 Homo sapiens
CTP:phosphocholine cytidylyltransferase-alpha
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 Homo sapiens

General Information

General Information Comment Organism
malfunction acute prelamin A accumulation after reduction of the activity of the ZMPSTE24 endoprotease by siRNA knockdown, results in the generation of a complex nucleoplasmic reticulum that depends for its formation on the CTP:phosphocholinecytidylyltransferase-a, this structure can form during interphase, confirming that it is independent of mitosis and therefore not a consequence of disordered nuclear envelope assembly Homo sapiens
physiological function nucleoplasmic reticulum development seems dependent on the enzyme CTP:phosphocholine-cytidylyltransferase-alpha, which is responsible for phosphatidylcholine synthesis for the biosynthesis and curvature of membranes, but nucleoplasmic reticulum development is independent of mitosis. Colocalisation of prelamin A and lamin B1 with a developing nucleoplasmic reticulum is dependent on CTP:phosphocholine-cytidylyltransferase-alpha Homo sapiens