Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
two isozymes CTalpha and CTbeta2 | - |
Rattus norvegicus | - |
two isozymes CTalpha and CTbeta2 | - |
Rattus norvegicus Sprague-Dawley | - |
two isozymes CTalpha and CTbeta2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
astrocyte | - |
Rattus norvegicus | - |
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
ganglion | superior cervical ganglia | Mus musculus | - |
ganglion | superior cervical ganglia | Rattus norvegicus | - |
neuron | Cortical, primary sympathetic and cultured primary, isozyme CTbeta2 mRNA and protein are abundant in distal axons of mouse sympathetic neurons, whereas isozyme CTalpha mRNA and protein are not detected | Mus musculus | - |
neuron | primary sympathetic and cultured primary, isozyme CTbeta2 mRNA and protein are abundant in distal axons of mouse sympathetic neurons, whereas isozyme CTalpha mRNA and protein are not detected | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
CTP:phosphocholine cytidylyltransferase-beta2 | - |
Mus musculus |
CTP:phosphocholine cytidylyltransferase-beta2 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | in cultured primary neurons nerve growth factor increases the amount of isozyme CTbeta2, but not CTalpha, mRNA and protein | up |
Rattus norvegicus | in cultured primary neurons nerve growth factor increases the amount of isozyme CTbeta2, but not CTalpha, mRNA and protein | up |
General Information | Comment | Organism |
---|---|---|
malfunction | isozyme CTbeta2 deficiency in distal axons reduces the incorporation of choline into by 95% whereas phosphatidylcholine synthesis in cell bodies/proximal axons is unaltered. Brains of mice lacking CTbeta2 have normal phosphatidylethanolamine content despite having 35% lower enzyme activity than wild-type brains. Axon branching, but not axon extension, is impaired in CTbeta2-deficient neurons. Phenotypes, overview | Mus musculus |
malfunction | isozyme CTbeta2 deficiency in distal axons reduces the incorporation of choline into by 95% whereas phosphatidylcholine synthesis in cell bodies/proximal axons is unaltered. Brains of mice lacking CTbeta2 have normal phosphatidylethanolamine content despite having 35% lower enzyme activity than wild-type brains. Axon branching, but not axon extension, is impaired in CTbeta2-deficient neurons. Phenotypes, overview | Rattus norvegicus |
physiological function | importance of isozyme CTbeta2 for phosphatidylcholine synthesis as well as for axon formation, growth and branching of primary sympathetic neurons | Mus musculus |
physiological function | importance of isozyme CTbeta2 for phosphatidylcholine synthesis as well as for axon formation, growth and branching of primary sympathetic neurons | Rattus norvegicus |