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Literature summary for 2.7.7.15 extracted from
- Calmodulin binds and stabilizes the regulatory enzyme, CTP:phosphocholine cytidylyltransferase (2007), J. Biol. Chem., 282, 33494-33506.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Q243A | the mutation results in loss of calmodulin binding and leads to complete calpain resistance in vitro and in vivo | Mus musculus |
General Stability
| General Stability | Organism |
|---|---|
| calmodulin stabilizes CCTalpha from calpain proteolysis | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| calpain | calpain degrades CCTalpha, 0.6 pmol of calpain effectively cleaves 80% of purified CCTalpha (0.7 pmol) in the absence of calmodulin | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
1 * 80000 + 1 * 30000 | Mus musculus |
| 80000 | - |
1 * 80000 + 1 * 30000 | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Mus musculus | diphosphate + CDP-choline | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 80000 + 1 * 30000 | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCTalpha | - |
Mus musculus |
| CTP:phosphocholine cytidylyltransferase | - |
Mus musculus |
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