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Literature summary for 2.7.7.15 extracted from

  • Bogan, M.J.; Agnes, G.R.; Pio, F.; Cornell, R.B.
    Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry (2005), J. Biol. Chem., 280, 19613-19624.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Lipids regulation of activity by reversible association with membranes containing anionic lipids Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in insect cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-
soluble CCTalpha Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41724
-
2 * 41724, calculated from the deduced amino acid sequence, 2 * 42211, mass spectrometry, phosphorylated protein Rattus norvegicus
42211
-
2 * 41724, calculated from the deduced amino acid sequence, 2 * 42211, mass spectrometry, phosphorylated protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
Rattus norvegicus diphosphate + CDP-choline
-
?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
?

Subunits

Subunits Comment Organism
dimer 2 * 41724, calculated from the deduced amino acid sequence, 2 * 42211, mass spectrometry, phosphorylated protein Rattus norvegicus