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Literature summary for 2.7.7.15 extracted from

  • Taneva, S.G.; Patty, P.J.; Frisken, B.J.; Cornell, R.B.
    CTP:phosphocholine cytidylyltransferase binds anionic phospholipid vesicles in a cross-bridging mode (2005), Biochemistry, 44, 9382-9393.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Lipids regulation of activity by reversible association with membrane lipids, activation of enzyme when bound to lipid vesicles, vesicles containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine or egg phosphatidylglycerol are more effective than vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 1,2-dioleoyl-sn-glycerol, or egg phosphatidylcholine Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in High 5 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein C-terminal region is highly phosphorylated, phosphorylation decreases membrane affinity and is therefore involved in regulation of enzyme activity Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
Rattus norvegicus diphosphate + CDP-choline
-
?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
?

Subunits

Subunits Comment Organism
dimer
-
Rattus norvegicus

Synonyms

Synonyms Comment Organism
CCTalpha
-
Rattus norvegicus