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Literature summary for 2.7.7.15 extracted from
- Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine (2004), Biochem. J., 382, 741-750.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glucosylceramide | - |
Mus musculus |  |
| glucosylceramide | - |
Rattus norvegicus | |
| Lipids | regulation of activity by reversible association with membrane lipids | Mus musculus | |
| Lipids | regulation of activity by reversible association with membrane lipids | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in mice | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ceramide | - |
Mus musculus | |
| ceramide | - |
Rattus norvegicus | |
| lysophosphatidylcholine | - |
Mus musculus | |
| lysophosphatidylcholine | - |
Rattus norvegicus | |
| sphingosine | sphingosine decreases CCTalpha protein and mRNA level | Mus musculus | |
| sphingosine | sphingosine decreases CCTalpha protein and mRNA level | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| membrane | enzyme is activated when bound to vesicles | Mus musculus | 16020 | - |
| membrane | enzyme is activated when bound to vesicles | Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | Mus musculus | rate limiting enzyme for the synthesis of phosphatidylcholine | diphosphate + CDP-choline | - |
? | |
| CTP + choline phosphate | Rattus norvegicus | rate limiting enzyme for the synthesis of phosphatidylcholine | diphosphate + CDP-choline | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | enzyme phosphorylation is involved in regulation of activity | Mus musculus |
| phosphoprotein | enzyme phosphorylation is involved in regulation of activity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | alveolar type II epithelial cells | Rattus norvegicus | - |
| lung | type II epithelia | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Mus musculus | diphosphate + CDP-choline | - |
? | |
| CTP + choline phosphate | - |
Rattus norvegicus | diphosphate + CDP-choline | - |
? | |
| CTP + choline phosphate | rate limiting enzyme for the synthesis of phosphatidylcholine | Mus musculus | diphosphate + CDP-choline | - |
? | |
| CTP + choline phosphate | rate limiting enzyme for the synthesis of phosphatidylcholine | Rattus norvegicus | diphosphate + CDP-choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCTalpha | - |
Mus musculus |
| CCTalpha | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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