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Literature summary for 2.7.7.15 extracted from

  • Yeo, H.J.; Larvor, M.P.; Ancelin, M.L.; Vial, H.J.
    Plasmodium falciparum CTP:phosphocholine cytidylyltransferase expressed in Escherichia coli: purification, characterization and lipid regulation (1997), Biochem. J., 324, 903-910.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
-
Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ concentrations above 40 mM are inhibitory Plasmodium falciparum
Mn2+ concentrations above 5 mM are inhibitory Plasmodium falciparum
NaCl inhibitory above 200 mM, 39% inhibition at 300 mM, 67% inhibition at 500 mM Plasmodium falciparum
sphingosine
-
Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.49
-
phosphocholine presence of lipid, pH 7.4, 37°C Plasmodium falciparum
0.66
-
phosphocholine absence of lipid, pH 7.4, 37°C Plasmodium falciparum
10.9
-
CTP presence of lipid, pH 7.4, 37°C Plasmodium falciparum
28.9
-
CTP absence of lipid, pH 7.4, 37°C Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ maximal activity at 10-40 mM, concentrations above 40 mM are inhibitory Plasmodium falciparum
Mn2+ can partially replace Mg2+, maximal activity at 5 mM, concentrations above 5 mM are inhibitory Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
SDS-PAGE Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
homogeneity Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate dCTP can replace CTP with reduced activity Plasmodium falciparum diphosphate + CDPcholine
-
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