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Literature summary for 2.7.7.15 extracted from
- Kinetic and biochemical properties of CTP:choline-phosphate cytidylyltransferase from the rat brain (1988), Eur. J. Biochem., 178, 367-372.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| fatty acids | activity slightly enhanced by addition of saturated fatty acids, markedly increased by addition of unsaturated fatty acids regardless of chain length and number of double bonds | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDPcholine | competitive to choline phosphate | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
choline phosphate | pH 7.4, 37°C | Rattus norvegicus | |
| 10 | - |
CTP | pH 7.4, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
| Mg2+ | 2-20 mM | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | Rattus norvegicus | rate limiting step in synthesis of phosphatidylcholine | diphosphate + CDPcholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| CTP + phosphocholine = diphosphate + CDP-choline | random mechanism | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Rattus norvegicus | diphosphate + CDPcholine | - |
? | |
| CTP + choline phosphate | rate limiting step in synthesis of phosphatidylcholine | Rattus norvegicus | diphosphate + CDPcholine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.09 | - |
CDPcholine | pH 7.4, 37°C | Rattus norvegicus | |
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