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Literature summary for 2.7.7.14 extracted from

  • Ando, H.; Horibata, Y.; Aoyama, C.; Shimizu, H.; Shinohara, Y.; Yamashita, S.; Sugimoto, H.
    Side-chain oxysterols suppress the transcription of CTP phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation (2019), J. Steroid Biochem. Mol. Biol., 195, 105482 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q99447
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Mus musculus Q922E4
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-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
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Hepa-1 cell
-
 Mus musculus
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NIH-3T3 cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
CTP:phosphoethanolamine cytidylyltransferase
-
 Mus musculus
CTP:phosphoethanolamine cytidylyltransferase
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 Homo sapiens
Pcyt2
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 Mus musculus
Pcyt2
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus increased Pcyt2 mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription down
Homo sapiens increased Pcyt2 mRNA levels after serum starvation are suppressed by 25-hydroxycholesterol. The suppressive effect of 25-hydroxycholesterol on mRNA transcription is ameliorated by trichostatin A. Anacardic acid, 25-hydroxycholesterol and 24(S)-hydroxycholesterol suppress the transcription by inhibiting H3K27 acetylation in the promoter. 27-Hydroxycholesterol, 22(S)-hydroxycholesterol and 22(R)-hydroxycholesterol suppress the transcription down
Mus musculus increased Pcyt2 mRNA levels after serum starvation up
Homo sapiens increased Pcyt2 mRNA levels after serum starvation up

General Information

General Information Comment Organism
metabolism rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis Mus musculus
metabolism rate-limiting enzyme in mammalian phosphatidylethanolamine biosynthesis Homo sapiens