Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
two splice variants, Pcyt2alpha and Pcyt2beta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CTP:ethanolaminephosphate cytidylyltransferase | - |
Homo sapiens |
Pcyt2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | serum-deficient MCF-7 cells adapt to stress conditions by increasing synthesis and content of phosphatidylethanolamine and diacylglycerol. The biosynthesis of phosphatidylethanolamine from diacylglycerol and ethanolamine is regulated at the level of formation of CDP-ethanolamine, the metabolic step catalyzed by Pcyt2. The catalytic activity of Pcyt2 is elevated 2-3fold, yet the enzyme remains rate-limiting in serum-deficient cells. The mRNA levels of two splice variants, Pcyt2alpha and Pcyt2beta, are 1.5-3fold higher in deficient cells. Elevated diacylglycerol formation and the increased activity of the rate-regulatory enzyme Pcyt2 are critical modulators of the phosphatidylethanolamine Kennedy pathway, and total phosphatidylethanolamine content in serum-deprived breast cancer cells | Homo sapiens |