Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Arabidopsis thaliana Col-0 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Arabidopsis thaliana | - |
Synonyms | Comment | Organism |
---|---|---|
GDP-mannose pyrophosphorylase | - |
Arabidopsis thaliana |
GMPase | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | the ascorbic acid-deficient Arabidopsis thaliana mutant vtc1-1 is defective in GDP-mannose pyrophosphorylase and exhibits conditional hypersensitivity to ammonium, a phenomenon that is independent of ascorbic acid deficiency. Defective N-glycosylation in vtc1-1 contributes to cell wall, membrane and cell cycle defects, resulting in root growth inhibition in the presence of NH4+, GDP-mannose deficiency does not generally lead to and is not the primary cause of NH4+ sensitivity. GDP-mannose deficiency results in an up-regulation of ER stress genes, enhanced programmed cell death and defective cell cycle proliferation in vtc1-1 triggered by NH4+, overview. Root development in the presence of NH4+ is fully recovered in vtc1-1 containing one wild-type copy of VTC1 | Arabidopsis thaliana |