Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for inhibitor design for anti-leishmanial therapy | Leishmania infantum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Leishmania infantum | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + alpha-D-mannose 1-phosphate | Leishmania infantum | - |
diphosphate + GDP-mannose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania infantum | A4I048 | clone JPCM5 (MCAN/ES/98/LLM-877) | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + alpha-D-mannose 1-phosphate | - |
Leishmania infantum | diphosphate + GDP-mannose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GDP-MP | - |
Leishmania infantum |
guanosine-diphospho-D-mannose pyrophosphorylase | - |
Leishmania infantum |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes a step in the mannose activation pathways and glycoconjugate biosynthesis in Leishmania, overview | Leishmania infantum |
additional information | a common motif of amino acids binds to the mannose moiety of the substrate and is specific to the catalytic site of the parasite enzyme, molecular dynamics and homology modeling, overview. Sequence comparison to the human enzyme | Leishmania infantum |
physiological function | the GDP-mannose pyrophosphorylase is involved in glycosylation and essential for amastigote survival | Leishmania infantum |