Cloned (Comment) | Organism |
---|---|
expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3)pLysS | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4E)-4-[(6-chloro-1,3-benzodioxol-5-yl)methylidene]-1-(3,4-dimethylphenyl)pyrazolidine-3,5-dione | - |
Leishmania major | |
(4Z)-1-(4-fluorophenyl)-4-[(5-methyltetrahydrofuran-2-yl)methylidene]pyrazolidine-3,5-dione | - |
Leishmania major | |
2-(5-ethyl-1,3,4-thiadiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione | - |
Leishmania major | |
2-methyl-9H-pyrido[2,3-b]indole | - |
Leishmania major | |
3-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)-1H-indole | - |
Leishmania major | |
3-(2-ethyl-5-methyl-2H-pyrrol-3-yl)-6-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
3-[2-(4-methoxyphenyl)ethyl]-2H-1,2,4-benzothiadiazine 1,1-dioxide | - |
Leishmania major | |
4-(4-benzylpiperazin-1-yl)-7-chloroquinoline | - |
Leishmania major | |
4-[4-(4-tert-butylbenzyl)piperazin-1-yl]-7-chloroquinoline | - |
Leishmania major | |
4-[4-(biphenyl-4-ylmethyl)piperazin-1-yl]-7-chloroquinoline | - |
Leishmania major | |
5-methyl-2-(2-phenylethyl)-1H-benzimidazole | - |
Leishmania major | |
6-(1-ethyl-3-propyl-1H-pyrazol-5-yl)-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
6-(2,4-dichlorophenyl)-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
6-(2-chloro-6-fluorobenzyl)-3-(2-ethyl-5-methyl-2H-pyrrol-3-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
6-(2-chloro-6-fluorobenzyl)-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
6-(4-chlorophenyl)-3-(2-methylbenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
6-(4-fluorophenyl)-3-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
6-[[(4,6-dimethylpyrimidin-2-yl)sulfanyl]methyl]-3-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | - |
Leishmania major | |
7-chloro-4-(4-methylpiperazin-1-yl)quinoline | - |
Leishmania major | |
7-methoxy-4-oxo-4H-thiochromene-3-carboxylic acid | - |
Leishmania major | |
8-(dimethylamino)-7-hydroxy-3-(1-phenyl-1H-pyrazol-4-yl)-4H-chromen-4-one | - |
Leishmania major | |
9-(3,4-dimethoxyphenyl)-2,3-dihydroimidazo[1,2-c]thieno[3,2-e]pyrimidine | - |
Leishmania major | |
ethyl (2Z)-(hydroxyimino)(1H-tetrazol-5-yl)ethanoate | - |
Leishmania major | |
methyl 1-cyano-2-hydroxy-9,10-dimethoxy-4-oxo-6,7-dihydro-4H-pyrido[2,1-a]isoquinoline-3-carboxylate | - |
Leishmania major | |
additional information | high-throughput GDP-MP inhibitor large-scale screening, overview | Leishmania major | |
[4-(7-chloroquinolin-4-yl)piperazin-1-yl](4-methylphenyl)methanone | - |
Leishmania major |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + alpha-D-mannose 1-phosphate | Leishmania major | - |
diphosphate + GDP-mannose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3)pLysS by metal affinity chromatograhy | Leishmania major |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Leishmania major | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + alpha-D-mannose 1-phosphate | - |
Leishmania major | diphosphate + GDP-mannose | - |
? | |
additional information | GDP-MP high-throughput screening assay method devlopment and evaluation, overview | Leishmania major | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GDP-mannose pyrophosphorylase | - |
Leishmania major |
GDP-MP | - |
Leishmania major |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Leishmania major |