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Literature summary for 2.7.7.10 extracted from
- Uridine diphosphoglucose pyrophosphorylase and uridine diphosphogalactose pyrophosphorylase in human skin fibroblasts derived from normal and galactosemic individuals (1972), Biochim. Biophys. Acta, 268, 113-120.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.18 | - |
diphosphate | healthy individuals, pH 7.8, 37°C | Homo sapiens |  |
| 0.22 | - |
diphosphate | galactosemic individuals, pH 7.8, 37°C | Homo sapiens | |
| 0.37 | - |
UDP-galactose | healthy persons, pH 7.8, 37°C | Homo sapiens | |
| 0.47 | - |
UDP-galactose | galactosemic individuals, pH 7.8, 37°C | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UTP + alpha-D-galactose 1-phosphate | Homo sapiens | alternate pathway of galactose metabolism | diphosphate + UDP-galactose | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skin fibroblast | from healthy and galactosemic individuals | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0025 | - |
healthy individuals | Homo sapiens |
| 0.0027 | - |
galactosemic individuals | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UTP + alpha-D-galactose 1-phosphate | - |
Homo sapiens | diphosphate + UDP-galactose | - |
r | |
| UTP + alpha-D-galactose 1-phosphate | alternate pathway of galactose metabolism | Homo sapiens | diphosphate + UDP-galactose | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
15 min, 70% loss of activity, t1/2: 7.5 min, enzyme from healthy individual, and 10 min, enzyme from galactosemic individual | Homo sapiens |
| 56 | - |
5 min, inactivation | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 8.6 | broad | Homo sapiens |
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Release 2023.1 (January 2023)
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