Literature summary for 2.7.7.1 extracted from

Hicks, A.N.; Lorenzetti, D.; Gilley, J.; Lu, B.; Andersson, K.E.; Miligan, C.; Overbeek, P.A.; Oppenheim, R.; Bishop, C.E.
Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo (2012), PLoS ONE, 7, e47869.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	highest expression	Mus musculus	-
embryo	-	Mus musculus	-
lung	low expression	Mus musculus	-
additional information	not expressed in heart, bladder, kidney and liver	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + nicotinamide ribonucleotide	-	Mus musculus	diphosphate + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
nicotinamide mononucleotide adenylyltransferase 2	-	Mus musculus
NMNAT2	isoform	Mus musculus

General Information

General Information	Comment	Organism
malfunction	nicotinamide mononucleotide adenylyltransferase 2 (Nmat2) homozygous deletion mutants show an approximate 60% reduction of spinal motoneurons in the lumbar region and a more than 80% reduction in the sensory neurons of the dorsal root ganglion. In the absence of Nmnat2, major target organs and tissues (e.g., muscle) are not functionally innervated resulting in perinatal lethality	Mus musculus
physiological function	nicotinamide mononucleotide adenylyltransferase 2 regulates axon integrity in the mouse embryo	Mus musculus

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Release 2023.1 (January 2023)