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Literature summary for 2.7.7.1 extracted from

  • Yahata, N.; Yuasa, S.; Araki, T.
    Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration (2009), J. Neurosci., 29, 6276-6284.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.1

Application

Application Comment Organism
medicine the mitochondrial localization of NMNAT activity plays an important role in NMNAT expression-mediated axonal protection Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
transgenic mice overexpressing NMNAT1 and the mutant WldS(W258A) are generated Mus musculus
transgenic mice overexpressing NMNAT3 are generated Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information naturally occuring mutant mice, wldS, showing delayed Wallerian degeneration phenotype, suggest that axonal degeneration is an active process, the wldS mutation comprises an 85 kb tandem triplicon, which causes overexpression of the chimeric WldS protein composed of the N-terminal 70 aa of Ufd2a/Ube4b, an ubiquitin-chain assembly factor, fused to the complete sequence of NMNAT1 Mus musculus
WldS(W258A) the chimeric WldS protein is composed of the N-terminal 70 aa of Ufd2a/Ube4b, an ubiquitin-chain assembly factor, fused to the complete sequence of NMNAT1, the W258A mutation disrupts the NAD-synthesizing activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Mus musculus 5759
-
mitochondrion
-
 Mus musculus 5739
-
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q99JR6 NMNAT3
-
Mus musculus Q9EPA7 NMNAT1
-

Purification (Commentary)

Purification (Comment) Organism
prepared from cerebrum for activity assays Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinamide ribonucleotide
-
 Mus musculus diphosphate + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
nicotinamide mononucleotide adenylyltransferase nicotinate nucleotide can also act as acceptor, see also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase Mus musculus
NMNAT
-
 Mus musculus
NMNAT1 nuclear isoform Mus musculus
NMNAT3 mitochondrial isoform Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity assay Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 activity assay Mus musculus

General Information

General Information Comment Organism
physiological function NMNAT1 is an enzyme in the NAD biosynthetic pathway that generates NAD in the nucleus Mus musculus