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Literature summary for 2.7.7.1 extracted from

  • Zhai, R.G.; Zhang, F.; Hiesinger, P.R.; Cao, Y.; Haueter, C.M.; Bellen, H.J.
    NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration (2008), Nature, 452, 887-891.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information overexpression of NAD synthase nicotinamide mononucleotide adenylyltransferase protects against spinocerebellar ataxia-induced neurodegeneration Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster NAD synthase nicotinamide mononucleotide adenylyltransferase is a stress-response protein that acts as a chaperone for neuronal maintenance and protection ?
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme is upregulated in the brain upon overexpression of poly-glutamine expanded protein Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NAD synthase nicotinamide mononucleotide adenylyltransferase is a stress-response protein that acts as a chaperone for neuronal maintenance and protection Drosophila melanogaster ?
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 ?
additional information NAD synthase nicotinamide mononucleotide adenylyltransferase displays chaperone function both in biochemical assays and cultured cells. It is upregulated in the brain upon overexpression of poly-glutamine expanded protein and recruited with the chaperone Hsp70 into protein aggregates. Drosophila melanogaster ?
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