Activating Compound | Comment | Organism | Structure |
---|---|---|---|
epigallocatechin gallate | 0.05 mM, 1.4fold activation, NMNAT3 | Homo sapiens | |
epigallocatechin gallate | 0.05 mM, 10% activation, NMNAT1 | Homo sapiens | |
epigallocatechin gallate | 0.05 mM, 2.28fold activation, NMNAT2 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
NMNAT1 | Homo sapiens |
NMNAT2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | NMNAT1; NMNAT2 | Homo sapiens | |
AMP | NMNAT2 | Homo sapiens | |
gallotannin | IC50: 0.002 mM, NMNAT3; IC50: 0.01 mM; IC50: 0.055 mM, NMNAT2 | Homo sapiens | |
NADP+ | NMNAT1; NMNAT2 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.029 | - |
ATP | NMNAT3 | Homo sapiens | |
0.032 | - |
nicotinamide ribonucleotide | NMNAT2 | Homo sapiens | |
0.034 | - |
nicotinamide ribonucleotide | NMNAT1 | Homo sapiens | |
0.04 | - |
ATP | NMNAT1 | Homo sapiens | |
0.059 | - |
NAD+ | NMNAT1 | Homo sapiens | |
0.07 | - |
NAD+ | NMNAT2 | Homo sapiens | |
0.13 | - |
NAD+ | NMNAT3 | Homo sapiens | |
0.204 | - |
ATP | NMNAT2 | Homo sapiens | |
0.209 | - |
nicotinamide ribonucleotide | NMNAT3 | Homo sapiens | |
0.39 | - |
diphosphate | NMNAT3 | Homo sapiens | |
0.937 | - |
diphosphate | NMNAT1 | Homo sapiens | |
1.119 | - |
diphosphate | NMNAT2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | NMNAT2 is assocaiated with | Homo sapiens | 5794 | - |
mitochondrion | NMNAT3 | Homo sapiens | 5739 | - |
nucleus | NMNAT1 is exclusively located in | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + nicotinamide ribonucleotide | Homo sapiens | central enzyme of NAD biosynthetic pathway | diphosphate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96T66 | isoform NMNAT3 | - |
Homo sapiens | Q9BZQ4 | isoform NMNAT2 | - |
Homo sapiens | Q9HAN9 | isoform NMNAT1 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
NMNAT1 | Homo sapiens |
NMNAT2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | NMNAT2 | Homo sapiens | - |
heart | NMNAT1 | Homo sapiens | - |
kidney | NMNAT1 | Homo sapiens | - |
lung | NMNAT3 | Homo sapiens | - |
skeletal muscle | NMNAT1 | Homo sapiens | - |
spleen | NMNAT3 | Homo sapiens | - |
Storage Stability | Organism |
---|---|
-80°C, NMNAT2 is stable | Homo sapiens |
4°C, NMNAT1 is stable | Homo sapiens |
4°C, stable | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + nicotinamide ribonucleotide | central enzyme of NAD biosynthetic pathway | Homo sapiens | diphosphate + NAD+ | - |
? | |
ATP + nicotinamide ribonucleotide | NMNAT1 | Homo sapiens | diphosphate + NAD+ | - |
r | |
ATP + nicotinamide ribonucleotide | NMNAT2 | Homo sapiens | diphosphate + NAD+ | - |
r | |
ATP + nicotinamide ribonucleotide | NMNAT3 | Homo sapiens | diphosphate + NAD+ | - |
r | |
GTP + nicotinamide ribonucleotide | 19% of the activity with GTP, reverse reaction with 57% of the activity with NAD+, NMNA3 | Homo sapiens | diphosphate + NGD+ | - |
r | |
GTP + nicotinamide ribonucleotide | 3% of the activity with GTP, reverse reaction with 5% of the activity with NAD+, NMNAT2 | Homo sapiens | diphosphate + NGD+ | - |
r | |
GTP + nicotinamide ribonucleotide | 7% of the activity with GTP, reverse reaction with 26% of the activity with NAD+, NMNAT1 | Homo sapiens | diphosphate + NGD+ | - |
r | |
ITP + nicotinamide ribonucleotide | 27% of the activity with ATP, NMNAT3 | Homo sapiens | diphosphate + nicotinamide hypoxanthine dinucleotide | - |
? | |
ITP + nicotinamide ribonucleotide | 5% of the activity with ATP, NMNAT2 | Homo sapiens | diphosphate + nicotinamide hypoxanthine dinucleotide | - |
? | |
ITP + nicotinamide ribonucleotide | 6% of the activity with ATP, NMNAT1 | Homo sapiens | diphosphate + nicotinamide hypoxanthine dinucleotide | - |
? | |
NADH + diphosphate | 53% of the activity with NAD+, NMNAT1 | Homo sapiens | ? | - |
? | |
NADH + diphosphate | 98% of the activity with NAD+, NMNAT2 | Homo sapiens | ? | - |
? | |
NADH + diphosphate | 99% of the activity with NAD+, NMNAT3 | Homo sapiens | ? | - |
? | |
nicotinamide hypoxanthine dinucleotide + diphosphate | 98% of the activity with NAD+, NMNAT3 | Homo sapiens | ? | - |
? | |
nicotinamide hypoxanthine dinucleotide + diphosphate | 37% of the activity with NAD+, NMNAT2 | Homo sapiens | ITP + nicotinamide ribonucleotide | - |
? | |
nicotinamide hypoxanthine dinucleotide + diphosphate | 55% of the activity with NAD+, NMNAT1 | Homo sapiens | ITP + nicotinamide ribonucleotide | - |
? | |
nicotinic acid adenine dinucleotide phosphate + diphosphate | 93% of the activity with NAD+, NMNAT1 | Homo sapiens | ? | - |
? | |
nicotinic acid adenine dinucleotide phosphate + diphosphate | 98% of the activity with NAD+, NMNAT2 | Homo sapiens | ? | - |
? | |
nicotinic acid adenine dinucleotide phosphate + diphosphate | as active as with NAD+, NMNAT3 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide mononucleotide adenylyltransferase | - |
Homo sapiens |
NMNAT1 | - |
Homo sapiens |
NMNAT2 | - |
Homo sapiens |
NMNAT3 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
IC50: 0.002 mM, NMNAT3 | Homo sapiens | gallotannin | |
0.01 | - |
IC50: 0.01 mM | Homo sapiens | gallotannin | |
0.055 | - |
IC50: 0.055 mM, NMNAT2 | Homo sapiens | gallotannin |