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Literature summary for 2.7.7.1 extracted from

  • Magni, G.; Amici, A.; Emanuelli, M.; Orsomando, G.; Raffaelli, N.; Ruggieri, S.
    Structure and function of nicotinamide mononucleotide adenylyltransferase (2004), Curr. Med. Chem., 11, 873-885.
    View publication on PubMed
Search for more literature for 2.7.7.1

Activating Compound

Activating Compound Comment Organism Structure
additional information SO42- has no effect Methanocaldococcus jannaschii
SO42- 0.1 M, 20fold activation Saccharolobus solfataricus

Inhibitors

Inhibitors Comment Organism Structure
ADP-ribose
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.023
-
 NAD+ isoform yNMNAT-2 Saccharomyces cerevisiae
0.073
-
 NAD+ isoform yNMNAT-1 Saccharomyces cerevisiae
0.083
-
 diphosphate isoform yNMNAT-1 Saccharomyces cerevisiae
0.11
-
 nicotinamide ribonucleotide isoform yNMNAT-1 Saccharomyces cerevisiae
0.13
-
 nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae
0.19
-
 ATP isoform yNMNAT-1 Saccharomyces cerevisiae
1.4
-
 ATP isoform yNMNAT-2 Saccharomyces cerevisiae
5
-
 diphosphate isoform yNMNAT-2 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
Co2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
Mg2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
Mg2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
Mn2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
Mn2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
Ni2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
Ni2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae
Zn2+ metal ion required. Order of decreasing effectiveness: Co2+, Ni2+, Mg2+, Zn2+, Mn2+, isoform yNMNAT-2 Saccharomyces cerevisiae
Zn2+ metal ion required. Order of decreasing effectiveness: Ni2+, Zn2+, Co2+, Mg2+, Mn2+, isoform yNMNAT-1 Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18600
-
 x * 18600, SDS-PAGE Saccharolobus solfataricus
19600
-
 x * 19600, SDS-PAGE Methanocaldococcus jannaschii
46000
-
 4 * 46000, isoform yNMNAT-2, SDS-PAGE Saccharomyces cerevisiae
48000
-
 4 * 48000, isoform yNMNAT-1, SDS-PAGE Saccharomyces cerevisiae
66000
-
-
 Saccharolobus solfataricus
72000
-
-
 Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + nicotinamide ribonucleotide Haemophilus influenzae final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Bacillus subtilis final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Homo sapiens final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Saccharomyces cerevisiae final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Bos taurus final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Methanothermobacter thermautotrophicus final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Saccharolobus solfataricus final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide Methanocaldococcus jannaschii final step in biosynthesis of NAD+ diphosphate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bos taurus
-
-
-
Haemophilus influenzae
-
-
-
Homo sapiens
-
-
-
Methanocaldococcus jannaschii
-
-
-
Methanothermobacter thermautotrophicus
-
-
-
Saccharolobus solfataricus
-
-
-
Saccharomyces cerevisiae
-
 isoform yNMNAT-1
-
Saccharomyces cerevisiae
-
 isoform yNMNAT-2
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
corpus luteum activity is high during mid luteal phase, when corpora lutea are mature with respect to structure and function, while it dramatically decreases following PGF2alpha analog injection Bos taurus
-
placenta
-
 Homo sapiens
-
testis
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinamide ribonucleotide
-
 Haemophilus influenzae diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide
-
 Bacillus subtilis diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide
-
 Bos taurus diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide
-
 Methanothermobacter thermautotrophicus diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide
-
 Saccharolobus solfataricus diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide
-
 Methanocaldococcus jannaschii diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Haemophilus influenzae diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Bacillus subtilis diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Homo sapiens diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Bos taurus diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Methanothermobacter thermautotrophicus diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Saccharolobus solfataricus diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide final step in biosynthesis of NAD+ Methanocaldococcus jannaschii diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide isoform yNMNAT-1 Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
ATP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + NAD+
-
 ?
CTP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide cytosine dinucleotide
-
 ?
dATP + nicotinamide ribonucleotide isoform yNMNAT-1 Saccharomyces cerevisiae diphosphate + ?
-
 ?
dATP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide deoxyadenosine dinucleotide
-
 ?
GTP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide guanine dinucleotide
-
 ?
ITP + nicotinamide ribonucleotide isoform yNMNAT-2 Saccharomyces cerevisiae diphosphate + nicotinamide hypoxanthine dinucleotide
-
 ?

Subunits

Subunits Comment Organism
? x * 18600, SDS-PAGE Saccharolobus solfataricus
? x * 19600, SDS-PAGE Methanocaldococcus jannaschii
hexamer
-
 Methanothermobacter thermautotrophicus
hexamer
-
 Methanocaldococcus jannaschii
tetramer
-
 Haemophilus influenzae
tetramer 4 * 46000, isoform yNMNAT-2, SDS-PAGE Saccharomyces cerevisiae
tetramer 4 * 48000, isoform yNMNAT-1, SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
hNMNAT-1
-
 Homo sapiens
nicotinamide mononucleotide adenylyltransferase
-
 Haemophilus influenzae
nicotinamide mononucleotide adenylyltransferase
-
 Bacillus subtilis
nicotinamide mononucleotide adenylyltransferase
-
 Homo sapiens
nicotinamide mononucleotide adenylyltransferase
-
 Saccharomyces cerevisiae
nicotinamide mononucleotide adenylyltransferase
-
 Bos taurus
nicotinamide mononucleotide adenylyltransferase
-
 Methanothermobacter thermautotrophicus
nicotinamide mononucleotide adenylyltransferase
-
 Saccharolobus solfataricus
nicotinamide mononucleotide adenylyltransferase
-
 Methanocaldococcus jannaschii
NMNAT
-
 Haemophilus influenzae
NMNAT
-
 Bacillus subtilis
NMNAT
-
 Saccharomyces cerevisiae
NMNAT
-
 Bos taurus
NMNAT
-
 Methanothermobacter thermautotrophicus
NMNAT
-
 Saccharolobus solfataricus
NMNAT
-
 Methanocaldococcus jannaschii
yNMNAT-1
-
 Saccharomyces cerevisiae
yNMNAT-2
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
90
-
 above Methanocaldococcus jannaschii
97
-
 above Saccharolobus solfataricus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
90
-
 half-life is 30 min Saccharolobus solfataricus
90
-
 half-life is 1 h Methanocaldococcus jannaschii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.8 7.8
-
 Saccharolobus solfataricus
6.5 8 isoform yNMNAT-2 Saccharomyces cerevisiae
7 8.5 isoform yNMNAT-1 Saccharomyces cerevisiae

pI Value

Organism Comment pI Value Maximum pI Value
Saccharomyces cerevisiae 4.2, 4.9 and 6.2, isoform yNMNAT-1
-
 4.2
Saccharomyces cerevisiae predicted, isoform yNMNAT-2
-
 5.6