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Literature summary for 2.7.7.1 extracted from
- Characterization of nicotinamide mononucleotide adenylyltransferase from thermophilic archaea (1997), J. Bacteriol., 179, 7718-7723.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Methanocaldococcus jannaschii |
General Stability
| General Stability | Organism |
|---|---|
| chaotropic anions are strong destabilizers of the enzyme | Saccharolobus solfataricus |
| increasing ionic strenght of NaCl and KCl stabilizes the thermal stability of the enzyme | Saccharolobus solfataricus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18600 | - |
x * 18600, SDS-PAGE | Saccharolobus solfataricus |
| 21500 | - |
x * 21500, SDS-PAGE | Methanocaldococcus jannaschii |
| 66000 | - |
- |
Saccharolobus solfataricus |
| 72000 | - |
gel filtration | Methanocaldococcus jannaschii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanocaldococcus jannaschii | - |
- |
- |
| Saccharolobus solfataricus | P57084 | - |
- |
| Saccharolobus solfataricus P2 | P57084 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Methanocaldococcus jannaschii |
- |
Saccharolobus solfataricus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | i.e. NMN or nicotinamide mononucleotide | Methanocaldococcus jannaschii | diphosphate + NAD+ | - |
r |  |
| ATP + nicotinamide ribonucleotide | i.e. NMN or nicotinamide mononucleotide | Saccharolobus solfataricus | diphosphate + NAD+ | - |
r | |
| ATP + nicotinamide ribonucleotide | i.e. NMN or nicotinamide mononucleotide | Saccharolobus solfataricus P2 | diphosphate + NAD+ | - |
r | |
| ATP + nicotinate ribonucleotide | i.e. nicotinate mononucleotide | Saccharolobus solfataricus | diphosphate + nicotinic acid-adenine dinucleotide | - |
r | |
| ATP + nicotinate ribonucleotide | i.e. nicotinate mononucleotide | Saccharolobus solfataricus P2 | diphosphate + nicotinic acid-adenine dinucleotide | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 18600, SDS-PAGE | Saccharolobus solfataricus |
| ? | x * 21500, SDS-PAGE | Methanocaldococcus jannaschii |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 97 | activity shows a continuous increase up to 97°C | Saccharolobus solfataricus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
stable for 6 h | Methanocaldococcus jannaschii |
| 80 | - |
half life: 3 h | Methanocaldococcus jannaschii |
| 80 | - |
stable at least 2 h | Saccharolobus solfataricus |
| 85 | - |
half life: 75 min | Saccharolobus solfataricus |
| 90 | - |
half life: 30 min | Saccharolobus solfataricus |
| 90 | - |
half life: 1 h | Methanocaldococcus jannaschii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.8 | 7.8 | - |
Saccharolobus solfataricus |
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