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Literature summary for 2.7.7.1 extracted from
- Nicotinamide mononucleotide adenylyltransferase activity in human erythrocytes (1993), Arch. Biochem. Biophys., 302, 206-211.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition by nicotinic acid and nicotinamide | Homo sapiens | |
| nicotinamide ribonucleotide | strong, nicotinate ribonucleotide as substrate | Homo sapiens |  |
| nicotinate ribonucleotide | nicotinamide ribonucleotide as substrate | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.147 | 0.2 | nicotinamide ribonucleotide | 37°C, pH 7.6 | Homo sapiens | |
| 0.5 | 0.52 | ATP | 37°C, pH 7.6 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | Homo sapiens | - |
diphosphate + NAD+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, in stroma-free lysate: 30% loss of activity within 2-3 days, in washed erythrocytes: up to 1 month | Homo sapiens |
| 0-3°C, E. coli enzyme: 31 days stable, yeast enzyme: 22% loss of activity within 31 days | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + nicotinamide ribonucleotide | - |
Homo sapiens | diphosphate + NAD+ | - |
r | |
| ATP + nicotinamide ribonucleotide | i.e. NMN or nicotinamide mononucleotide | Homo sapiens | diphosphate + NAD+ | - |
r | |
| ATP + nicotinate ribonucleotide | i.e. nicotinate mononucleotide | Homo sapiens | diphosphate + nicotinic acid-adenine dinucleotide | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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