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Literature summary for 2.7.6.3 extracted from

  • Chhabra, S.; Newman, J.; Peat, T.S.; Fernley, R.T.; Caine, J.; Simpson, J.S.; Swarbrick, J.D.
    Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus (2010), Acta Crystallogr. Sect. F, 66, 575-578.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.6.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method, using 1.08 M sodium malonate pH 7, 0.09 M bis-Tris pH 6.5, 0.175 M sodium formate, and 0.01 M sodium acetate pH 4.6 Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex 75 gel filtration Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 6-hydroxymethyl-7,8-dihydropteridine
-
 Staphylococcus aureus AMP + 6-hydroxymethyl-7,8-dihydropteridine diphosphate
-
 ir

Synonyms

Synonyms Comment Organism
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
-
 Staphylococcus aureus
HPPK
-
 Staphylococcus aureus

General Information

General Information Comment Organism
metabolism 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinae is a committed enzyme in the folate pathway of Streptococcus aureus playing an integral role in the biosynthesis of tetrahydrofolate Staphylococcus aureus