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Literature summary for 2.7.6.3 extracted from

  • Dittrich, S.; Mitchell, S.L.; Blagborough, A.M.; Wang, Q.; Wang, P.; Sims, P.F.; Hyde, J.E.
    An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites (2008), Mol. Microbiol., 67, 609-618.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.6.3

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Plasmodium falciparum
Mg2+
-
 Toxoplasma gondii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 6-hydroxymethyl-7,8-dihydropterin Plasmodium falciparum fourth step in folate biosynthesis, detailed overview AMP + (7,8-dihydropterin-6-yl)methyl diphosphate
-
 ?
ATP + 6-hydroxymethyl-7,8-dihydropterin Toxoplasma gondii fourth step in folate biosynthesis, detailed overview AMP + (7,8-dihydropterin-6-yl)methyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-
Toxoplasma gondii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 6-hydroxymethyl-7,8-dihydropterin fourth step in folate biosynthesis, detailed overview Plasmodium falciparum AMP + (7,8-dihydropterin-6-yl)methyl diphosphate
-
 ?
ATP + 6-hydroxymethyl-7,8-dihydropterin fourth step in folate biosynthesis, detailed overview Toxoplasma gondii AMP + (7,8-dihydropterin-6-yl)methyl diphosphate
-
 ?
ATP + 6-hydroxymethyl-7,8-dihydropterin the enzyme is absolutely specific for the substrate Plasmodium falciparum AMP + (7,8-dihydropterin-6-yl)methyl diphosphate
-
 ?
ATP + 6-hydroxymethyl-7,8-dihydropterin the enzyme is absolutely specific for the substrate Toxoplasma gondii AMP + (7,8-dihydropterin-6-yl)methyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
-
 Plasmodium falciparum
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
-
 Toxoplasma gondii
HPPK
-
 Plasmodium falciparum
HPPK
-
 Toxoplasma gondii
PPPK
-
 Plasmodium falciparum
PPPK
-
 Toxoplasma gondii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Plasmodium falciparum
37
-
 assay at Toxoplasma gondii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Plasmodium falciparum
8
-
 assay at Toxoplasma gondii

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Plasmodium falciparum
ATP
-
 Toxoplasma gondii