Application | Comment | Organism |
---|---|---|
additional information | Administration of oxythiamine to animals produces primarily metabolic aberrations such as lethargy and anorexia while the administration of pyrithiamine to animals produces neurological problems similar to Wernicke-Korsakoff Syndrome. | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
Crystallization experiments were set up by incubating mouse TPK with pyrithiamine and MgATP2- prior to adding the equilibrium mixture of enzyme, substrate, and products to the previously determined crystallization conditions. | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pyrithiamine | - |
Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thiamine + ATP | Mus musculus | - |
thiamine diphosphate + AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
oxythiamine + ATP | - |
Mus musculus | oxythiamine diphosphate + AMP | - |
? | |
pyrithiamine + ATP | inhibits the substrate thiamine | Mus musculus | pyrithiamine diphosphate + AMP | - |
? | |
thiamine + ATP | - |
Mus musculus | thiamine diphosphate + AMP | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
thiamine pyrophosphokinase | - |
Mus musculus |