Literature summary for 2.7.6.2 extracted from

Fraccascia, P.; Sniekers, M.; Casteels, M.; Van Veldhoven, P.P.
Presence of thiamine pyrophosphate in mammalian peroxisomes (2007), BMC Biochem., 8, 10.

Search for more literature for 2.7.6.2

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	exclusively	Rattus norvegicus	5829	-
cytosol	exclusively	Mus musculus	5829	-
additional information	no enzyme localization in the peroxisome, subcellular localization analysis, overview	Rattus norvegicus	-	-
additional information	no enzyme localization in the peroxisome, subcellular localization analysis, overview	Mus musculus	-	-
peroxisome	Peroxisomes are devoid of thiamine pyrophosphokinase activity.	Rattus norvegicus	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + thiamine	Rattus norvegicus	importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes	AMP + thiamine diphosphate	-	?
ATP + thiamine	Mus musculus	importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes	AMP + thiamine diphosphate	-	?
thiamine + ATP	Rattus norvegicus	TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase.	thiamine diphosphate + AMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q59Q36	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-
liver	-	Mus musculus	-
skeletal muscle	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + thiamine	-	Rattus norvegicus	AMP + thiamine diphosphate	-	?
ATP + thiamine	-	Mus musculus	AMP + thiamine diphosphate	-	?
ATP + thiamine	importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes	Rattus norvegicus	AMP + thiamine diphosphate	-	?
ATP + thiamine	importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes	Mus musculus	AMP + thiamine diphosphate	-	?
thiamine + ATP	TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase.	Rattus norvegicus	thiamine diphosphate + AMP	-	?

Synonyms

Synonyms	Comment	Organism
thiamine pyrophokinase	-	Rattus norvegicus
thiamine pyrophosphokinase	-	Rattus norvegicus
thiamine pyrophosphokinase	-	Mus musculus
TPK	-	Rattus norvegicus
TPK	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus
ATP	-	Mus musculus

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Release 2023.1 (January 2023)